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Molecular basis of chromosome segregation

Andrea Musacchio


Andrea Musacchio
c/o IFOM-IEO Campus
Via Adamello, 16 - 20139 Milan, Italy
Tel. +39 02 57489829 - +39 02 57489871
Fax +39 0294375990

Selected publications

  • Villa F, Capasso P, Tortorici M, Forneris M, de Marco A, Mattevi A & Musacchio A
    Crystal structure of the catalytic domain of Haspin, an atypical kinase implicated in chromatin organization
    PNAS 106:20204-9. (2009)
  • Nezi L & Musacchio A
    Sister chromatid tension and the spindle assembly checkpoint
    Curr Opin Cell Biol. 21(6):785-95 (2009)
  • Santaguida S & Musacchio A
    The life and miracles of kinetochores
    EMBO J 28:2511-31 (2009)
  • Simonetta M, Manzoni R, Mosca R, Mapelli M, Massimiliano L, Vink M, Novak B, Musacchio A* & Ciliberto A*
    The influence of catalysis on Mad2 activation dynamics
    PLoS Biology 7, e10 (2009)
    (*corresponding authors)
  • Ciferri C, Pasqualato S, Screpanti E, Varetti G, Santaguida S, Dos Reis G, Maiolica A, Polka J, De Luca JG, De Wulf P, Salek M, Rappsilber J, Moores CA, Salmon ED & Musacchio A
    Implications for kinetochore-microtubule attachment from the structure of an engineered Ndc80 complex
    Cell 133, 427-439 (2008)
  • Mapelli M, Massimiliano L, Santaguida S & Musacchio A
    The Mad2 Conformational Dimer: Structure and Implications for the Spindle Assembly Checkpoint
    Cell 131, 730-43 (2007)
  • Derewenda U, Tarricone C, Choi W-C, Cooper DR, Lukasik S, Perrina F, Tripathy A, Kim M-H, Cafiso DS, Musacchio A & Derewenda ZS
    The structure of the coiled-coil domain of Ndel1 and the basis of its interaction with Lis1, the causal protein of Miller-Dieker lissencephaly
    Structure 15, 1467-81 (2007)
  • Musacchio A & Salmon ED
    The spindle assembly checkpoint in space and time
    Nature Rev Mol Cell Biol, 8, 379-93 (2007)
  • DeLuca JG, Gall WE, Ciferri C, Cimini D, Musacchio A & Salmon ED
    Kinetochore microtubule dynamics and attachment stability are regulated by Hec1
    Cell 127, 969-82 (2006)
  • Nezi L, Rancati G, De Antoni A, Pasqualato S, Piatti S & Musacchio A
    Accumulation of Mad2-Cdc20 complex during spindle checkpoint activation requires binding of open and closed conformers of Mad2 in Saccharomyces cerevisiae
    J Cell Biol. 174, 39-51 (2006)
  • Vink M, Simonetta M, Transidico P, Ferrari K, Mapelli M, De Antoni A, Massimiliano L, Ciliberto A, Faretta M, Salmon ED & Musacchio A
    In vitro FRAP identifies the minimal requirements for Mad2 kinetochore dynamics.
    Curr Biol. 16, 755-66 (2006)
  • Mapelli M, Filipp FV, Rancati G, Massimiliano L, Nezi L, Stier G, Hagan RS, Confalonieri S, Piatti S, Sattler M & Musacchio A
    Determinants of conformational dimerization of Mad2 and its inhibition by p31(comet)
    EMBO J 25, 1273-8 (2006)
  • Penengo L, Mapelli M, Murachelli AG, Confalonieri S, Magri L, Musacchio A, Di Fiore PP, Polo S, Schneider TR
    Crystal Structure of the Ubiquitin Binding Domains of Rabex-5 Reveals Two Modes of Interaction with Ubiquitin
    Cell 124, 1183-1195 (2006)
  • Claudio Ciferri, Jennifer De Luca, Silvia Monzani, Karin Ferrari, Dejan Ristic, Claire Wyman, Holger Stark, John Kilmartin, E.D. Salmon & Andrea Musacchio
    Architecture of the human Hec1/Ndc80 complex, a critical constituent of the outer kinetochore
    J. Biol. Chem. 280, 29088-29095 (2005)
  • Sessa F, Mapelli M, Ciferri C, Tarricone C, Areces LB, Schneider TR, Stukenberg PT and Musacchio A
    Mechanism of Aurora-B activation by INCENP and inhibition by Hesperadin
    Mol. Cell 18, 379-391. (2005)
  • De Antoni A, Pearson CG, Cimini D, Canman J, Sala V, Nezi L, Mapelli M, Sironi L, Faretta M, Salmon ED and Musacchio A,
    The Mad1/Mad2 Complex as a Template for Mad2 Activation in the Spindle Assembly Checkpoint
    Curr. Biol. 15, 214-225 (2005)
  • Mapelli M, Massimiliano L, Crovace C, Seeliger MA, Tsai LH, Meijer L, Musacchio A
    Mechanism of CDK5/p25 Binding by CDK Inhibitors
    J Med. Chem. 48, 671-679 (2005)
  • Tarricone C, Perrina F, Monzani F, Massimiliano L, Kim M-H, Derewenda ZS, Knapp S, Tsai L-H and Musacchio A
    Coupling PAF signaling to dynein regulation: structure of LIS1 in complex with PAF-acetylhydrolase
    Neuron 44, 809-821 (2004)
  • Steensgaard P, Garrč M, Muradore I, Transidico P, Nigg E, Kitagawa K, Earnshaw WC, Faretta M and Musacchio A,
    Sgt1 is required for human kinetochore assembly
    EMBO Reports 5, 626-631 (2004)
  • Musacchio A and Hardwick K
    The spindle checkpoint: structural insights into dynamic signalling
    Nat Rev Mol Cell Biol, 10, 731-41 (2002)
  • Sironi L, Mapelli M, Knapp S, De Antoni A, Jeang K-T and Musacchio A
    Structure of the tetrameric Mad1-Mad2 core complex: implications of a 'safety belt' binding mechanism for the spindle checkpoint
    EMBO J, 21, 2496-2506 (2002)
  • Sironi L, Melixetian M, Faretta M, Prosperini E, Helin K, and Musacchio A
    Mad2 binding to Mad1 and Cdc20, rather than oligomerization, is required for the spindle checkpoint
    EMBO J. 20, 6371-82 (2001)
  • Tarricone C, Dhavan R, Peng J, Areces L, Tsai L-H, and Musacchio A
    Structure and regulation of the CDK5-p25 complex
    Molecular Cell 8, 657-669 (2001)
update: January 2010
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